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Introduction of Eotaxin

    

 

 

Eotaxin is a member of the CC family of chemokines, so called because of their conserved two N-terminal cysteine residues.

 

The hallmark of the CC chemokines in general is their ability to chemoattract and activate inflammatory leucocytes, particularly lymphocytes, monocytes, eosinophils and basophils, as well as some stromal cells such as endothelial and smooth muscle cells. An important, and probably related function is their ability to induce diapedesis of cells across vascular endothelium, a function of obvious relevance to the propagation of tissue inflammation. A final notable effect of some of the CC chemokines, including eotaxin, is their ability to cause IgE-independent degranulation of basophils.These activities of CC chemokines are mediated through a family of receptors belonging to the 7 transmembrane-spanning (serpentine) superfamily.

 

ELISA(enzyme-linked immunosorbent assay) is a method for detecting the concentration of some kind antigen or antibody,such as eotaxin and CC chemokine receptors, using the characteristic of specific binding between antigen-antibody.The method is suitable for determination of cell culture supernatant, serum, plasma,tissue fluid, and urine samples. Meretciel provide quality ELISA kits for R&D,can use to study the role of eotaxin and CC chemokine receptors.

 

At present, nine CC chemokine receptors (CCR1–9) have been described, and it seems likely that further receptors (as well as further CC chemokines) will be discovered, especially using techniques such as expression sequence tag screening. In general, any particular CC chemokine can bind to several CC receptors. Eotaxin (and eotaxin-2) are exceptional in this regard, since they bind only to the CCR3 receptor. Thus far, only a limited range of cells has been found to express CCR3: eosinophils, basophils, ‘Th2-type’ T cells and microglial cells in the central nervous system.

 

 

Thus, only eotaxin and eotaxin-2 can chemoattract and activate these target cells specifically. While other CC chemokines (MCP-2, MCP-3, MCP-4 and RANTES) may exert a similar range of effects on these target cells by binding to CCR3, these chemokines are less specific in the sense that they also bind to CC chemokine receptors other than CCR3 on a wider range of target cells.

 

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