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Role of interferon-gamma during innate and adaptive immune r

    

 

 

Role of interferon-gamma during innate and adaptive immune responses

 

Wheelock reported that phytohemagglutinin could induce from human leukocytes an interferon-like virus inhibitor in 1965. This substance, which turned out to be interferon-gamma (IFN-gamma). Past research has led to the general conclusion that IFN-gamma is much more than an interferon in that it has broader effects on the various arms of the immune system than most any other lymphokine or cytokine.

 

Scientists discuss the effects of IFN-gamma on the various cell lineages of the immune system, focusing on the biology of its actions. In addition,They summarize research focused on the consequences of introducing IFN-gamma cDNA into tumor cells, aberrant IFN-gamma production in transgenic animals, and inhibition of IFN-gamma effects by knocking out either the IFN-gamma gene itself or the IFN-gamma receptor gene.

 

ELISA(enzyme-linked immunosorbent assay) is a method for detecting the concentration of some kind antigen or antibody,such as IFN-gamma, using the characteristic of specific binding between antigen-antibody. The method is suitable for determination of cell culture supernatant, serum, plasma,tissue fluid, and urine samples. Meretciel provide high quality ELISA kits for R&D,can study the role of IFN-gamma.

 

IFN-gamma is crucial for immunity against intracellular pathogens and for tumor control. However, aberrant IFN-gamma expression has been associated with a number of autoinflammatory and autoimmune diseases. This cytokine is produced mainly by T-cells and natural killer cells  as part of the innate immune response, and by Th1 CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.

 

Researchers recent insights regarding the molecular regulation of IFN-gamma, focusing on work that has led to the identification and characterization of distal regulatory elements and epigenetic modifications with the IFN-gamma locus (Ifng) that govern its expression. The epigenetic modifications and three-dimensional structure of the Ifng locus in naive CD4 T cells, and the modifications they undergo as these cells differentiate into effector T cells.It suggest that a model whereby the chromatin architecture of Ifng is poised to facilitate either rapid opening or silencing during Th1 or Th2 differentiation, respectively.

 

 

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